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Associate Principal Scientist - ADME/PKPD

Requisition ID: PHA001528

Merck Research Laboratories South San Francisco, a wholly owned subsidiary of Merck and Co., is focused on driving discovery research. Our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with Merck's world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay area's biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of Merck's powerful world-class network of drug and vaccine discovery.

At Merck, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At Merck Research Labs South San Francisco, you'll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

The Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) department of MRL at South San Francisco is seeking a dynamic, strategic-thinking, and collaborative scientist for the Absorption, Distribution, Metabolism and Excretion (ADME) group. The Associate Principal Scientist will be primarily discovery team-facing and be expected to visibly be a key contributor to the multi-disciplinary drug discovery effort for various therapeutics (small molecule, antibody-drug conjugate, peptide, and biologic therapeutics) that are most likely to succeed clinically. The candidate will need to regularly engage with partner functions like medicinal and computational chemistry, translational pharmacology, pharmaceutics, and toxicology. Therapeutic areas will include immunology, oncology, cardiovascular and metabolic disease, and ophthalmology.

The responsibilities of the Associate Principal Scientist will be to work collaboratively in a fast-paced environment to contribute to the prediction, design, implementation, and analysis of in silico, in vitro, and in vivo studies. Those studies will characterize and build an understanding of key structure-activity relationships (SAR) related to ADME and pharmacological properties, therapeutic disposition, and translational pharmacokinetic-pharmacodynamic/efficacy (tPKPD/E) relationships. The candidate will be able to leverage the understanding of molecular characteristics impacting disposition and tPKPD/E relationships to guide both drug design and implementation of strategy(ies) for the translation of preclinical results to anticipated clinical efficacy. Excellent scientific, interpersonal, and communication skills are required. The candidate will be expected to effectively present their work at discovery team and departmental meetings as well as promote Merck science through publications and presentations/lectures.


Education Minimum Requirement:

PhD, MS, or BS degrees in Pharmaceutical Sciences, Chemistry, Biochemistry, Immunology, Pharmacology, Engineering, or related science.

Required Experience and Skills**:

PhD (3+ year), MS (+8 years), BS (+12 years) of combined industry and/or postdoctoral (or fellowship) experience focused on providing ADME support for optimization of small molecule, antibody-drug conjugate, peptide, and/or biologic therapeutics.

Strategically used structure-activity relationships (SAR) related to ADME and pharmacological properties to drive optimization of therapeutics.

Contributed to development, execution, and fostering of translational pharmacokinetic-pharmacodynamic/efficacy (tPKPD/E) relationships and other useful quantitative pharmacology applications in a discovery setting.

Strong leadership, interpersonal, communication, problem solving, and collaboration skills along with strengths in delivering results in fast-pace environment.

Technical understanding of ADME assays and instrumental analysis.

Demonstrated inclination towards recognition in the field, creativity and innovation via a strong publication/presentation record.

Preferred Experience and Skills:

Hands-on experience in computational ADME predictions and visualizations (eg, GastroPlus, simCYP, Spotfire).

Hands-on experience performing translational pharmacokinetic-pharmacodynamic/efficacy (tPKPD/E) and physiologically-based pharmacokinetic (PBPK) software modeling (eg, Phoenix WinNonlin, Berkeley Madonna, and/or MATLAB).

The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives. If you need an accommodation for the application process please email us at

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for us all.

Job: Pharmacokinetics/Drug Metab
Other Locations:
Employee Status: Regular
Travel: Yes, 5 % of the Time
Number of Openings: 1
Shift (if applicable): 1st
Hazardous Materials:
Company Trade Name: Merck

Nearest Major Market: San Francisco
Nearest Secondary Market: Oakland

Associate Principal Scientist - ADME/PKPD

South San Francisco, CA
Full Time

Published on 07/05/2019