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Associate Principal Scientist, Biochemistry and Ultra High-Throughput Mass Spectrometry

Job Description

If this position will be based in the US or Puerto Rico (not applicable to positions based outside of US or Puerto Rico):  Subject to applicable law,  all prospective hires will be required to demonstrate that they have been fully vaccinated for COVID-19 or intend to be vaccinated for COVID-19 by November 1, 2021, or qualify for a medical or religious accommodation to this vaccination requirement.  Hired candidates who are not vaccinated by November 1, 2021, and who have not been approved for a legally-required medical or religious accommodation will be subject to disciplinary action up to and including termination of employment, subject to applicable law.

The Biochemistry and Ultra-High Throughput Mass Spectrometry group within the Quantitative Biosciences Department is seeking a highly motivated and experienced candidate to fill the position of Associate Principal Scientist in Kenilworth NJ.  The successful candidate will be part of a multidisciplinary team driving early discovery programs for oncology, neuroscience, cardiovascular, and infectious disease areas. The ideal candidate will be adept in biochemical assay systems and have experience in the application of mass spectrometry to these assays.  Experience with developing methods using matrix-assisted laser desorption ionization (MALDI) or electrospray ionization (ESI) techniques is required.  Your role will be a complement and core resource to synergize with existing capabilities and will serve as a means to expand our ability to interrogate and identify new chemical matter to help drive our discovery programs.  You will have the opportunity to work independently and to proactively collaborate with colleagues in SCP, Quantitative Biosciences, Discovery Chemistry, IT, and across therapeutic area disciplines.

The successful candidate will join our team of experienced and accomplished colleagues, and will have the following responsibilities:

  • Independently develop assays to characterize enzyme activity in a biochemical context (e.g., determine substrate KM, Vmax, linearity) and validate these following NIH guidelines for high-throughput screening.

  • Utilize state of the art (ultra)high-throughput MS capabilities (including Echo-MS and MALDI-MS) to measure enzyme and cellular pathway activity for the purpose of high-throughput screening.

  • Develop sensitive and specific mass spectrometry methods for the quantitative analysis of a diverse range of analytes (small molecules, lipids, peptides, and proteins) from a variety of samples, with the emphasis on biochemical and cell-based assays.

  • Act as liaison on projects between research sites (NJ, PA, MA & CA).

  • Contribute to a strong, external scientific reputation for the department through publications and presentations at scientific conferences.



  • Post-graduate degree in Biochemistry, Pharmacology, Analytical Chemistry, or other relevant fields are welcome to apply:

  • Ph.D. +/- relevant postdoctoral experience, with 3 or more years of industry related experience

  • M.Sc. with 10+ years of job experience in a relevant academic (e.g., core lab) or industrial setting


  • Proven experience and knowledge in biochemistry, enzymology, assay development, and/or mechanism of action studies is required.

  • Proven expertise in quantitative analysis using mass spectrometry on samples of biological origin (recombinant enzyme systems, cell media and/or lysate, plasma, serum, tissue or other biofluids).

  • Hands-on proficiency developing methods using electrospray ionization (ESI) or matrix-assisted laser desorption ionization (MALDI) techniques is required.  Preference will be given to candidates with expertise in both approaches.

  • Demonstrated ability to independently diagnose, troubleshoot and resolve problems with MS instrumentation (triple quadrupole, (Q-)ToF and/or orbitrap systems).

  • Strong interpersonal, verbal, and written communication skills.

  • Proven track record of impactful research & communication, evidenced through peer-reviewed publications and presentations at scientific symposia.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. 

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully 
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

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Requisition ID:R146096

Associate Principal Scientist, Biochemistry and Ultra High-Throughput Mass Spectrometry

Kenilworth, NJ
Full Time

Published on 12/03/2021

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