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Associate Principal Scientist, Oncology Discovery

Requisition ID: BIO005393

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century. Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

We are looking for a passionate and energetic scientist to join the Oncology discovery biology team at Merck Research Labs, located in the Longwood Medical campus in Boston, MA. Oncology research at Merck is driven by a deep interest in the basic biology of the tumor microenvironment and how diverse points of intervention can be combined to achieve ever higher rates of durable response and patient overall survival. We believe that cells of the immune system are central to tissue repair and homeostasis mechanisms not only in the tumor microenvironment but also in other pathological processes such as neurodegeneration.

We are seeking an Associate Principal Scientist with demonstrated experience of driving research projects, with training in immunology, ideally human immunology. You will have a track record of results from collaborative projects as well as demonstrate excellent communication skills, particularly in the presentation and discussion of complex data and hypotheses.

In this exciting role, you will:

  • Collaborate with colleagues to define and execute upon a concerted effort to understand the role of myeloid cells in the TME as a basis for selecting and prioritizing drug targets.
  • Utilize your scientific expertise, network, and collaboration skills to deliver differentiated drug discovery projects, data-driven decision-making, and ultimately progression of new drug candidates in the Merck pipeline.
  • Maintain a presence in the lab at the same time as collaborating with scientists across the Merck network as well as academic investigators and industry partners.
  • Contribute to the evaluation of business and licensing opportunities


Education Minimum Requirements:

  • A Ph.D. in Immunology or related field

Required Experience and Skills:

  • A minimum of 2 years' experience, (in addition to postdoctoral experience), either as academic faculty or in a biotech/pharmaceutical setting
  • Prior experience supervising the work of others, demonstrating the ability to organize and guide their efforts.
  • Technical experience the following areas: isolation, culture and characterization of primary human immune cells, especially myeloid cells, using flow or mass cytometry; functional assays including cytokine release, migration assays, proliferation assays.
  • Demonstrate an appreciation of receptor pharmacology and ideally in vivo pharmacokinetics and pharmacodynamics.
  • Working knowledge of target identification and validation
  • Committed team player, working toward our shared goal of saving and improving the lives of patients.
  • Acute appreciation for the need to make definitive progress against objectives in a timely fashion.

Preferred Experience and Skills:

  • Experience developing new, fit-for-purpose in vitro functional assays, especially in immunology, including development of phenotypic screening approaches.
  • Experience with basic molecular biology and recombinant protein expression, gene editing, gene expression, sequencing and epigenetic profiling, or cell signaling assays.
  • Experience in the study of microglial function and neuro inflammation, including co-culture with primary neurons, would also be of interest.

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we're counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we're inventing for life.

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to .

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Merck & Co., Inc. is not accepting unsolicited assistance from search firms for this employment opportunity. Please, no phone calls or emails. All resumes submitted by search firms to any employee at Merck via email, the Internet or in any form and/or method without a valid written search agreement in place for this position will be deemed the sole property of Merck. No fee will be paid in the event the candidate is hired by Merck as a result of the referral or through other means.

Visa sponsorship is not available for this position.

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Merck is an equal opportunity employer, Minority/Female/Disability/Veteran - proudly embracing diversity in all of it's manifestations.

Job: Biology-Discovery
Other Locations:
Employee Status: Regular
Travel: Yes, 5 % of the Time
Number of Openings: 1
Shift (if applicable): N/A
Hazardous Materials: Chemical, biological, radiological
Company Trade Name: Merck

Nearest Major Market: Boston

Associate Principal Scientist, Oncology Discovery

Boston, MA
Full Time

Published on 02/05/2019