Quality Control Microbiology Scientist II
11/15/2023,
Novo Nordisk
Lebanon, NH
Scientist | Laboratory | Compliance | Microbiology
Associate Scientist / Scientist - Tissue Systems, Cell Production and R&D
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Associate Scientist / Scientist - Tissue Systems, Cell Production and R&D
The job details are as follows:
What We Do
We build on the strength of our research and development expertise and a distinctive, entrepreneurial culture that encourages diversity, innovation, creativity, sustainability, and, simply, fun. Since inception, our mission has been to find a cure for pulmonary arterial hypertension and other life-threatening diseases. Toward this goal we have successfully gained FDA approval for five medicines, we are always conducting new clinical trials, and we are working to create an unlimited supply of manufactured organs for transplantation.
We are the first publicly-traded biotech or pharmaceutical company to take the form of a public benefit corporation (PBC). Our public benefit purpose is to provide a brighter future for patients through (a) the development of novel pharmaceutical therapies; and (b) technologies that expand the availability of transplantable organs. At the same time, we seek to provide our shareholders with superior financial performance and our communities with earth-sensitive energy utilization.
Our company was founded by an entrepreneur whose daughter was diagnosed with a life-threatening condition. She sought to find treatment options and a cure for her daughter and patients like her. We are founder-led, and relentless in our pursuit of “medicines for life”. We continue to research and develop treatments for cardiovascular and pulmonary diseases, and other orphan diseases.
How you’ll contribute
Associate Scientist Level of Cell Production & R&D will contribute to efforts in developing and implementing robust process methods for the reprogramming of somatic cells and differentiation of iPS-derived cells for development of autologous 3D printed tissue engineered organs. The incumbent and team will also be tasked with supplying sufficient cells for R&D cellularization efforts in 3D printed lung scaffolds.
- Contribute to the development of a robust, autologous reprograming process from circulating cell types
- Contribute to the development and implementation of robust process methods for the production of primary and/or iPS-derived cells for tissue engineering of lungs, liver, and kidney
- Contribute to the production effort, including internal and external production, to provide sufficient cells for R&D cellularization efforts of 3D printed scaffolds
- Contribute to academic and industry collaborations and facilitate tech transfer activities from outside collaborators to internal laboratory
- Contribute to the development and implementation of analytic methods to characterize quality and suitability of iPS-derived cells for generation of 3D printed organs
- Design and execute laboratory experiments that lead to the successful achievement of program objectives
- Foster and leverage synergistic interactions with other sub-groups in Organ Manufacturing (e.g., Bioink, Scaffold Production, Cellularization), as needed
- Participate in selection, purchase, and implementation of laboratory equipment
- Develop, write and review laboratory methods and protocols
- Assist in the effective tech transfer activities from outside collaborators to internal laboratory
- Assist in evaluating new technologies for future process development
- Interact with manufacturing team to ensure process and methods for production of iPS-derived cells are GMP ready
- Author and contribute to scientific publications and present data at scientific conferences
- Author and contribute to IP and regulatory filings
- Perform all other duties as assigned
Scientist Level of Cell Production & R&D will lead efforts in developing and implementing robust process methods for the reprogramming of somatic cells and differentiation of iPS-derived cells for development of autologous 3D printed tissue engineered organs. The incumbent will also be tasked with supplying sufficient cells for R&D cellularization efforts in 3D printed lung scaffolds.
- Lead the development of a robust, autologous reprograming process from circulating cell types.
- Lead the development and implementation of robust process methods for the production of primary and/or iPS-derived cells for tissue engineering of lungs, liver, and kidney
- Contribute to the production effort, including internal and external production, to provide sufficient cells for R&D cellularization efforts of 3D printed scaffolds
- Contribute to academic and industry collaborations and facilitate tech transfer activities from outside collaborators to internal laboratory
- Contribute to the development and implementation of analytic methods to characterize quality and suitability of iPS-derived cells for generation of 3D printed organs
- Design and execute laboratory experiments that lead to the successful achievement of program objectives
- Foster and leverage synergistic interactions with other sub-groups in Organ Manufacturing (e.g., Bioink, Scaffold Production, Cellularization), as needed
- Perform selection, purchase, and implementation of laboratory equipment
- Develop, write and review laboratory methods and protocols
- Conduct the effective tech transfer activities from outside collaborators to internal laboratory
- Evaluate new technologies for future process development
- Collaborate with manufacturing team to ensure process and methods for production of iPS-derived cells are GMP ready
- Author and contribute to scientific publications and present data at scientific conferences
- Author and contribute to IP and regulatory filings
- Perform all other duties as assigned
For this role you will need
Associate Scientist Level Minimum Requirements:
- Master’s degree (MA/MS/MBA) in biomedical engineering, cell biology, molecular biology, or other related discipline and 3+ years of relevant experience including experience in stem cell differentiation, reprogramming, bioreactor cell production scale up, regenerative medicine, tissue engineering OR
- Doctor of Philosophy (PhD) in biomedical engineering, cell biology, molecular biology, or other related discipline and some relevant experience including experience in stem cell differentiation, reprogramming, bioreactor cell production scale up, regenerative medicine, tissue engineering
- Technical expertise in iPS-reprogramming and/or differentiation methods
- Facility with appropriate word processing, spreadsheet, presentation and related standard software; Experience with laboratory instrumentation and data software
- Ability to mentor and motivate team members
- Advanced written and oral communication skills
Scientist Level Minimum Requirements:
- Master’s degree (MA/MS/MBA) in biomedical engineering, cell biology, molecular biology, or other related discipline and 6+ years of relevant experience including experience in stem cell differentiation, reprogramming, bioreactor cell production scale up, regenerative medicine, tissue engineering OR
- Doctor of Philosophy (PhD) in biomedical engineering, cell biology, molecular biology, or other related discipline and 2+ years of relevant experience including experience in stem cell differentiation, reprogramming, bioreactor cell production scale up, regenerative medicine, tissue engineering
- Technical expertise in iPS-reprogramming and/or differentiation methods
- Facility with appropriate word processing, spreadsheet, presentation and related standard software; Experience with laboratory instrumentation and data software
- Ability to lead, mentor and motivate team members
- Advanced written and oral communication skills
Associate Scientist & Scientist Level Preferred Qualifications:
- Technical expertise in cell bioreactor culture including Ambr systems and vertical wheel bioreactors with scales up to 10L+
- Expertise in automated cell processing equipment such CliniMACS Plus, LOVO, Cue, Sepax, Sefia, Rotea and others
- Knowledge in transfer of R&D cell expansion methods to GMP
At United Therapeutics, you’ll realize quickly that it is not an ordinary place to work! When you join our company, you will learn, grow, contribute, have fun, and be challenged... all while making a difference in the lives of our patients.
- #LI-Onsite
While United Therapeutics does not require vaccination for Covid-19 at this time, we strongly encourage all employees and visitors to remain up to date on vaccinations and boosters to protect one another from illness. Employees working in customer-facing roles must adhere and comply with customers’ credentialing guidelines, which may require vaccination against Covid -19, the influenza virus, and other illnesses that could be harmful to healthcare staff and patients.
United Therapeutics Corporation is an Equal Opportunity/Affirmative Action Employer - EOE Minorities / Females / Protected Veterans / Individuals with Disabilities