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Postdoctoral Research Fellow - Discovery Oncology

Requisition ID: POS000283

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century . Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

Be a part of the legacy: MRL Postdoctoral Research Fellow Program.

The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

As a postdoctoral fellow in Merck Research Labs Discovery Oncology group based in Boston, MA, you will work with a highly collaborative team of scientists to design, develop and validate in in vivo tumor models, ex vivo/in vitro assays and gene profiling to elucidate the immunological consequences of resistance to cancer immunotherapy at cellular and molecular levels. This work will enable understanding of the functional roles of adaptive and innate immune components in the context of tumor intrinsic and acquired resistance to different immunotherapeutic platforms.

Responsibilities include but are not limited to:

  • Employing in vivo mouse models to address questions salient to the mechanism(s) of resistance to tumor immunotherapy.
  • Performing immunophenotyping and gene profiling experiments using a variety of techniques including but not limited multiparameter flow cytometry and mRNA profiling, e.g. single cell mRNAseq.
  • Collaborating with Merck and external scientists conducting in vivo tumor model studies to correlate and validate the in vitro assays.
  • Data interpretation, manuscript preparation, publication and presentation of results.
  • Contribute to a safe and compliant laboratory work environment.



Education Minimum Requirement:

  • A PhD with less than (3) years of postdoctoral experience OR graduating with a PhD by summer of 2019.

Required Experience and Skills:

  • Experience with mouse tumor model systems.
  • Multiparameter flow cytometry of mouse immune cells.
  • Proficiency in ex vivo/in vitro assays to test T and NK cell functions.
  • Ability to conceive, design, execute and communicate complex experiments.
  • Strong history of publication in peer-reviewed journals.
  • Must be an independent and self-motivated scientist.

Preferred Experience and Skills:

  • Tumor immunology/Cancer immunotherapy.
  • Molecular biology, bioinformatics, genomics experience.
  • Viral immunology in a chronic infection setting.
  • Human immunology.

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we're counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we're inventing for life.

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to

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Job: Post-Doctoral Fellow
Other Locations:
Employee Status: Regular
Travel: No
Number of Openings: 1
Shift (if applicable): N/A
Hazardous Materials:
Company Trade Name: Merck

Nearest Major Market: Boston

Postdoctoral Research Fellow - Discovery Oncology

Boston, MA
Full Time

Published on 08/06/2019