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Postdoctoral Research Fellow - Immunopeptidomics & Chemical Biology Proteomics

Requisition ID: POS000265

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where Merck has codified its legacy for over a century . Merck's success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.

Merck is on a quest for cures and is committed to being the world's premier, most research-intensive biopharmaceutical company. Today, we're doubling down on this goal. Merck Research Laboratories is a true scientific research facility of tomorrow, and will take Merck's leading discovery capabilities and world-class small molecule and biologics R&D expertise to create breakthrough science that radically changes the way we approach serious diseases.

Be a part of the legacy: MRL Postdoctoral Research Fellow Program

The Merck Research Laboratories (MRL) Postdoctoral Research Fellow Program aims to be a best-in-industry program for industrial postdoctoral researchers, designed to provide you with an academic focus in a commercial environment. With the resources, reach, and expertise of a large pharmaceutical company, postdoctoral researchers will be positioned to excel in an institution committed to breakthrough innovation in research and discovery.

As a Postdoctoral Fellow in the Chemical Biology Chemoproteomics group based in Boston, MA, you will work with an interdisciplinary and highly collaborative team of scientists to design and implement novel chemical, analytical, and biological methods for investigating antigen presentation, primarily through proteomic technologies. This work will enable understanding of antigen presentation biology and improve capabilities for cancer neoantigen discovery towards development of oncology vaccines.

Responsibilities include but are not limited to:

  • Developing and optimizing innovative biochemical and proteomic workflows.
  • Establishing tumor models to evaluate immunopeptidome modulation.
  • Bioinformatic analysis of deep datasets.
  • Presentation and publication of experimental results.



Education Minimum Requirement:

  • A PhD with less than (3) years of postdoctoral experience OR graduating with a PhD by summer of 2019.

Required Experience and Skills:

  • Experience in common tissue culture techniques.
  • Experience and working knowledge of biochemistry and molecular biology techniques including Western blotting, immunoaffinity precipitation (IP), and transfection.
  • Ability to learn and operate independently.
  • History of publication in peer-reviewed journals.

Preferred Experience and Skills:

  • Background in cellular immunology or the application of proteomics or peptidomics for immunology research.
  • Hands-on experience in mass spectrometry is beneficial but not necessary.
  • Working knowledge of bioinformatic tools; preferably experience with R or a scripting language.
  • Experience in culturing primary cells, organoids, or other 3D culture systems.
  • Knowledge of chemical biology approaches and their applications.

Your role at Merck is integral to helping the world meet new breakthroughs that affect generations to come, and we're counting on your skills and inventiveness to help make meaningful contributions to global medical advancement. At Merck, we're inventing for life.

If you need assistance and/or a reasonable accommodation due to a disability during the application or the recruiting process, please send a request to

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Job: Post-Doctoral Fellow
Other Locations:
Employee Status: Regular
Travel: No
Number of Openings: 1
Shift (if applicable):
Hazardous Materials:
Company Trade Name: Merck

Nearest Major Market: Boston

Postdoctoral Research Fellow - Immunopeptidomics & Chemical Biology Proteomics

Boston, MA
Full Time

Published on 05/07/2019