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Research and Development San Francisco

Job Description

The In Vitro Pharmacology group within our Research and Development team in South San Francisco is tasked with the unique responsibility in not only providing critical assay development support but also discovering innovative methods of building stronger automation capabilities specifically for assay development. Through this initiative, the Assay Development & Lab Automation Scientist will be provided the opportunity to not only apply their scientific experience/strengths to where it is needed, but also further develop and expand their skills in other areas within the field.

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

The team is seeking an experienced Assay Development Scientist with a strong background in biochemical/cellular assays and lab automation. This individual will participate in a wide range of laboratory research activities, including assay development/optimization, compound screening/characterization, mechanism of action studies, and new technology development. As part of a multidisciplinary team with broad scientific and technical expertise, he or she will have the opportunity to contribute to highly integrated drug discovery projects across multiple therapeutic areas (cardiovascular, metabolic, immunology and oncology). Successful candidates should possess strong experimental and technical capabilities, have excellent analytical and communication skills, and excel in a highly collaborative cross-functional team environment.

Key responsibilities:

"· Design, perform and interpret experimental studies with limited supervision to support early-stage drug discovery projects for both small molecules and biologics.

"· Develop, optimize and execute high-throughput biochemical and cell-based assays for compound screening, pharmacological characterization and SAR support.

"· Utilize advanced laboratory automation and informatics tools for assay operation, and participate in the training, evaluation and implementation of new technology platforms.

"· Conduct complex mechanism of action studies and detailed data analysis, and provide thorough documentation and communication of results to functional and project teams.

Education Minimum Requirement:

"· BS/MS degree in Biochemistry, Cell Biology, Pharmacology or a related scientific discipline

Required Experience and Skills**:

"· A minimum of 6 years of laboratory experience in early-stage drug discovery research at a biotech or pharma setting

"· Broad knowledge of biochemistry, cell biology/immunology, pharmacology and assay development principles is required, as well as solid experimental design, troubleshooting and data analysis skills

"· Strong expertise in biochemical and cellular assay development using diverse measurement technologies that should include several of the followings: ELISA, MSD, FP, TR-FRET, AlphaScreen, receptor binding/signaling, fluorescence imaging, and reporter assays

"· Mammalian cell culture and septic techniques are essential

"· Highly skilled in molecular techniques for gene targeting/editing and cell line generation, such as RNAi, viral transduction, CRISPR and exogenous gene expression

"· Hands-on experience in laboratory automation (including liquid handlers, dispensers and integrated robotics) and application process development.

"· An energetic self-starter and team player with excellent organization and communication skills, highly flexible and responsive to evolving project needs

Preferred Experience and Skills:

"· Prior experience in immune cell isolation/differentiation and immunological assays (flow cytometry and imaging)

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we "follow the science" and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Merck & Co., Inc., Kenilworth, New Jersey, USA is known as "Merck" in the United States, Canada & Puerto Rico. We are known as "MSD" in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world's biggest investors in Research & Development.

What we look for ...

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.





In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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We are an equal opportunity employer, Minority/Female/Disability/Veteran - proudly embracing diversity in all of its manifestations.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

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Requisition ID:RES002230

Research and Development San Francisco

South San Francisco, CA
Full Time

Published on 09/25/2019