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Scientist – In Vitro Neuroimmunology- Boston, MA

Job Description

Our Company's Neuroimmunology team in Boston, MA is seeking an independent and motivated scientist with a background in cell biology, immunology, and/or neuroscience to join us in validating and advancing novel neuroimmune targets for CNS diseases. As a Scientist, you will apply your knowledge and skillsets to establish assay systems and deliver datasets that will impact pipeline programs. Working in this lab-based position, your primary role will be to execute in vitro experiments including designing, establishing, and characterizing cell-based model systems, especially induced pluripotent stem cell (IPSC) models, and performing analysis in support of established and emerging therapeutic discovery programs. Successful candidates will be able to work independently and will be expected to proactively collaborate with colleagues across disciplines. The candidate will be an active participant in the positive and critical scientific dialogue that supports our mission of discovering novel immune-based therapies for CNS diseases.  

The responsibilities of the Neuroimmunology team member include:

  • Design, execute, analyze data and report in vitro experimental results.

  • Develop, troubleshoot, and validate new protocols and methods for cell based model systems with an emphasis on IPSC derived systems.

  • Collaborate across our Company's Discovery sites to maximize potential of iPSC work.

  • Excellent oral and written communication of data in a clear and concise manner to the appropriate teams and stakeholders.

  • Monitor and review published work to guide internal research.


  • BS/BA degree with a minimum 4 years of industry or biotechnology experience, preferably in neuroscience or pharmacology or a related subject area or a Master’s Degree in related subject area.


  • Demonstrated ability to thrive independently and in a team environment.

  • Experience culturing immune cell lines, primary murine microglia and iPSC-derived microglia

  • Application of standard laboratory cell culture procedures including DNA transfection, viral delivery and immunocytochemistry

  • Independently able to perform tissue and cellular protein/RNA preps, quantitative PCR, western blots, and ELISA

  • Strong data analysis skills including a knowledge of statistics.

  • Excellent oral and written communication skills, including preparation of study reports, presentations and able to contribute manuscripts for publication in peer reviewed journals.


  • Experience preparing and executing assays utilizing iPSC-derived cell models.

  • Primary neuronal/astrocyte culture experience

  • Stable cell line generation

  • Application of high-content imaging to cell-based assays

  • Experience with multiple therapeutic modalities (small molecule, antibody, peptide, siRNA).

  • Experience in neuroscience and pharmaceutical research; Alzheimer’s, Parkinson’s and ALS disease experience preferred

  • Record of innovative thinking to champion new ideas and solve problems reflected by contributions to peer reviewed publication.

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. 

Who we are …

We are known as Merck & Co., Inc., Rahway, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

Imagine getting up in the morning for a job as important as helping to save and improve lives around the world. Here, you have that opportunity. You can put your empathy, creativity, digital mastery, or scientific genius to work in collaboration with a diverse group of colleagues who pursue and bring hope to countless people who are battling some of the most challenging diseases of our time. Our team is constantly evolving, so if you are among the intellectually curious, join us—and start making your impact today.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

Residents of Colorado

Click here to request this role’s pay range.


New hires in office-based roles in the US & Puerto Rico will be required, subject to applicable law, to demonstrate that they have been fully vaccinated for COVID-19 or qualify for a medical or religious exemption to this vaccination requirement that can be accommodated without an undue burden to the operation. However, subject to applicable law, employees working in roles that the Company determines require routine collaboration with external stakeholders, such as employees in health services, customer facing commercial, or research based roles, will be required to be fully vaccinated as a condition of employment.

Current Employees apply HERE

Current Contingent Workers apply HERE

US and Puerto Rico Residents Only:

Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

EEOC Poster

EEOC GINA Supplement​

OFCCP EEO Supplement

Pay Transparency Nondiscrimination

We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Residents of Colorado:

Click here to request this role’s pay range.

Search Firm Representatives Please Read Carefully 
Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

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Requisition ID:R198514

Scientist – In Vitro Neuroimmunology- Boston, MA

Boston, MA
Full Time

Published on 09/23/2022

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