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Senior Scientist

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Using innovative thinking, state-of-the-art facilities and robust scientific methodology, we collaborate to discover the next medical breakthrough.

At our Company, the Biologics Upstream Process Development (BUPD) department within the Biologics Process Research & Development (BPR&D) organization is responsible for developing microbial and mammalian cell lines, media, and production processes, for early and late-stage biologics programs. BUPD group collaborates with internal and external organizations to rapidly develop cell lines and processes for novel and diverse biotherapeutics. In addition, we work very closely with our internal manufacturing site for the transfer and implementation of these processes for clinical supply production. For late-stage programs, we partner with our Manufacturing Division to support the commercialization of new biologics products. Our department is seeking a highly motivated scientist to support the technology innovation and process development using mammalian and microbial expression systems, leading to the transfer of high-yield, robust, and scalable production processes for biologics manufacturing.

As a Senior Scientist, the successful candidate will apply sound scientific understanding and engineering principles to develop, optimize, scale-up, and transfer production processes. He/She will independently conceptualize and execute microbial and/or cell culture studies leading to innovation and implementation in our pipeline. The candidate will be responsible for improving process automation and control to streamline our processes and operations. He/She will work in a very collaborative and matrix environment to innovate and establish new technologies and production platforms. The individual is expected to demonstrate strong communication skills in writing, presenting, and publishing the results, observations, and conclusions from scientific studies. In addition to the core responsibilities outlined above, the candidate is expected to follow good documentation practices, comply with all required training, and maintain focused attention on their own and team’s laboratory safety.

Education Minimum Requirement:  

  • Ph.D. in Chemical or Biochemical Engineering with some recent years of academic or industrial experience with microbial/yeast fermentation and/or cell culture processes.

Required Experience and Skills: 

  • Technical background and hands-on experience with different expression systems, microbial/yeast fermentation, cell culture techniques, and general laboratory practices, to produce recombinant proteins

  • Mechanistic and empirical modeling of production systems based on fundamental principles of metabolism and bioreactor design leveraging metabolic flux analysis, cellular kinetics, and omics tools for model building

  • Understanding of statistical methods (design of experiment, multivariate data analysis) and tools (SIMCA, JMP, Matlab)

  • Understanding and experience with computer programming packages (R, Python) to improve process automation

  • Understanding and implementation experience with control systems, in the context of microbial and/or mammalian production process

  • Ability to comprehend and execute experiments independently, and to fulfill the project objectives by meeting quality and timeline expectations

  • Ability to conceptualize, execute, analyze, present, and publish original hypothesis and applications in microbial or cell culture processes and technologies

  • Demonstrated ability to manage, analyze, and present complex datasets

  • Strong organizational, interpersonal, writing, and time management skills

  • Ability to work effectively in a functional and cross-functional collaborative environment, and to objectively drive results for the team

  • Collaborate and maintain a relationship with internal and external partners including vendors

Preferred Experience and Skills:

  • Scientific understanding of cell biology, metabolism, and engineering principles for recombinant protein production using microbial and mammalian hosts.

  • Experience with applying cell and/or process engineering approaches for scientific investigation, troubleshooting, process improvement, and product quality control. 

  • Expertise in bioanalytical techniques to characterize microbial or cell culture processes

  • Proven track records of scientific publication and communication with excellent oral and written skills

  • Understanding and experience of process automation programing and bioreactor operation including ambr15, ambr250, and 3L bioreactors is highly preferred   

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. 

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.





In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

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Requisition ID:R88874

Senior Scientist

Kenilworth, NJ
Full Time

Published on 01/14/2021