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Senior Scientist - ADME

Requisition ID: PHA001527

Merck Research Laboratories South San Francisco, a wholly owned subsidiary of Merck and Co., is focused on driving discovery research. Our new multi-disciplinary discovery research site offers state-of- the-art resources to explore the most promising science combined with Merck's world-class R&D expertise in small molecules and biologics. Located within the heart of the Bay area's biomedical community, research conducted in our new laboratories spans exploratory biology through early clinical development and is an integral part of Merck's powerful world-class network of drug and vaccine discovery.

At Merck, we are inspired by the belief that a research-driven enterprise dedicated to scientific excellence can create medicines and vaccines that save and improve lives. Every employee is building on our proud legacy of scientific breakthrough. Our ability to impact the lives of patients worldwide depends on the integrity, creativity, humility and scientific acumen of our team. We are creating a diverse organization that is inspired by invention and founded on a culture of respect and collaboration. At Merck Research Labs South San Francisco, you'll have the opportunity to expand your knowledge and skills through collaboration with talented and dedicated colleagues while advancing your career.

The Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) department of MRL at South San Francisco is seeking a dynamic, strategic-thinking, and collaborative scientist for the Absorption, Distribution, Metabolism and Excretion (ADME) group. The Senior Scientist will initially be lab-facing, but scientist will be developed to be increasing independent and discovery team-facing for small molecule, antibody-drug conjugate, peptide, and/or biologic therapeutics. The candidate will need to regularly engage with experimentalists and instrumental analysts in PPDM and in other functions.

The responsibilities of the Senior Scientist will be to work collaboratively in a fast-paced environment to design and interpret experiments, to be proficient in the upkeep of instruments, and to be training other technical staff in both instrumental and data analysis. Experiments will characterize and build an understanding of key structure-activity relationships (SAR) related to ADME properties. Excellent scientific, interpersonal, and communication skills are required. The candidate will be expected to effectively present their work at departmental meetings as well as promote Merck science through publications and presentations/lectures.


Education Minimum Requirement:

PhD, MS, or BS degrees in Pharmaceutical Sciences, Chemistry, Biochemistry, Immunology, Pharmacology, Engineering, or related science.

Required Experience and Skills**:

PhD (0-3 year), MS (+4 years), BS (+7 years) of combined industry and/or postdoctoral (or fellowship) experience focused on providing ADME support for optimization of small molecule, antibody-drug conjugate, peptide, and/or biologic therapeutics.

Strong leadership, interpersonal, communication, problem solving, and collaboration skills along with strengths in delivering results in fast-pace environment.

Preferred Experience and Skills:

Develop ADME assays tailored to the chosen therapeutic and in the relevant disease setting.

Have been exposed to and have some understanding of therapeutic exposure-effect relationships and physiologically-based pharmacokinetic (PBPK) software modeling.

The quality of our team is essential to our success. We are creating a new and innovative approach to rewarding our employees and establishing a comprehensive value proposition. Our competitive compensation program and benefits are designed to support the wide range of goals, needs and lifestyles of our employees, and the people that matter the most in their lives. If you need an accommodation for the application process please email us at

Merck & Co., Inc. Kenilworth, N.J., U.S.A. known as Merck in the United States and Canada, is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. Today, we are building a new kind of healthcare company - one that is ready to help create a healthier future for us all.

Job: Pharmacokinetics/Drug Metab
Other Locations:
Employee Status: Regular
Travel: Yes, 5 % of the Time
Number of Openings: 1
Shift (if applicable): 1st
Hazardous Materials:
Company Trade Name: Merck

Nearest Major Market: San Francisco
Nearest Secondary Market: Oakland

Senior Scientist - ADME

South San Francisco, CA
Full Time

Published on 07/05/2019