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Sr. Scientist, ADME

Job Description

We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world's biggest investors in Research & Development.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.




The Pharmacokinetics, Pharmacodynamics and Drug Metabolism (PPDM) department of our Research & Development Division at South San Francisco is seeking a dynamic, strategic-thinking, and collaborative scientist for the Absorption, Distribution, Metabolism and Excretion (ADME) group. The Senior Scientist will initially be lab-facing, but scientist will be developed to be increasing independent and discovery team-facing for small molecule, antibody-drug conjugate, peptide, and/or biologic therapeutics. The candidate will need to regularly engage with experimentalists and instrumental analysts in PPDM and in other functions.

The responsibilities of the Senior Scientist will be to work collaboratively in a fast-paced environment to design and interpret experiments, to be proficient in the upkeep of instruments, and to be training other technical staff in both instrumental and data analysis. Experiments will characterize and build an understanding of key structure-activity relationships (SAR) related to ADME properties. Excellent scientific, interpersonal, and communication skills are required. The candidate will be expected to effectively present their work at departmental meetings as well as promote our Company's science through publications and presentations/lectures.

Education Minimum Requirement:

  • PhD, MS, or BS degrees in Pharmaceutical Sciences, Chemistry, Biochemistry, Immunology, Pharmacology, Engineering, or related science.

Required Experience and Skills:

  • PhD (0-3 year), MS (+4 years), BS (+7 years) of combined industry and/or postdoctoral (or fellowship) experience focused on providing ADME support for optimization of small molecule, antibody-drug conjugate, peptide, and/or biologic therapeutics.
  • Strong leadership, interpersonal, communication, problem solving, and collaboration skills along with strengths in delivering results in fast-pace environment.

Preferred Experience and Skills:

  • Develop ADME assays tailored to the chosen therapeutic and in the relevant disease setting.
  • Have been exposed to and have some understanding of therapeutic exposure-effect relationships and physiologically-based pharmacokinetic (PBPK) software modeling.

If you need an accommodation for the application process please email us at

For more information about personal rights under Equal Employment Opportunity, visit:

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OFCCP Pay Transparency Rule

We are an equal opportunity employer, Minority/Female/Disability/Veteran - proudly embracing diversity in all of its manifestations.

Search Firm Representatives Please Read Carefully
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status:


VISA Sponsorship:

Travel Requirements:

Flexible Work Arrangements:

1st - Day

Valid Driving License:

Hazardous Material(s):

Number of Openings:

Requisition ID:PHA001527

Sr. Scientist, ADME

South San Francisco, CA
Full Time

Published on 09/10/2019