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Senior Scientist, Cytometric Profiling

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

The Cytometric Profiling group at our Company's Research & Development Division in South San Francisco is seeking a PhD scientist to lead the new mass cytometry profiling effort for preclinical oncology and non-oncology discovery programs.  Because our group manages the FACS core lab, this position also requires the candidate to have expertise in flow cytometry acquisition and analysis.

Our group is involved in both forward and reverse translational studies, performing immunophenotyping and developing a wide range of primary cell-based assays using fresh tissues of human, non-human primate, or murine origin. Experience with cell sorting is also highly desired, as cell sorting and downstream mRNA profiling (bulk or single-cell) is a mainstay of our profiling capabilities. The candidate will work with program team members as well as with other intradepartmental groups to contribute data for regulatory filings of the many new therapeutics entering the clinic. Importantly, this position requires a candidate who has excellent oral and written communication skills and who will enjoy working with a large group of scientists.

Education Minimum Requirement

  • Minimum of a PhD in Immunology, Biology, Biochemistry, or relevant discipline plus 0-3 years of industry experience

Required Experience and Skills

  • Experience with Mass Cytometry using the CyTOF technology
  • Experience with Flow Cytometry, preferably with BD Biosciences flow cytometers and acquisition software
  • Expertise in Mass Cytometry and Flow Cytometry panel design
  • Proficiency with high-dimensional data analytical methods such as tSNE, viSNE, CITRUS, FlowSOM, etc.
  • Immunology background
  • Excellent communication and interpersonal skills
  • Proficiency with MS Office applications on the Windows operating system

Preferred Experience and Skills

  • Cell sorting (FACS)
  • Cell preparation for single cell RNA-sequencing
  • Ex vivo functional assays such as proliferation, phospho-flow, or intracellular cytokine staining
  • Proficiency with TIBCO Spotfire

We are a research-driven bio-pharmaceutical company. Our mission is built on the simple premise that if we “follow the science” and that great medicines can make a significant impact to our world. And we believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe.

Who we are …

Merck & Co., Inc., Kenilworth, New Jersey, USA is known as “Merck” in the United States, Canada & Puerto Rico. We are known as “MSD” in Europe, Middle East, Africa, Latin America & Asia Pacific. We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.





In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

Employee Status:




VISA Sponsorship:


Travel Requirements:


Flexible Work Arrangements:

Work Week


Not Indicated

Valid Driving License:


Hazardous Material(s):

BSL2 laboratory

Number of Openings:


Requisition ID:R7447

Senior Scientist, Cytometric Profiling

South San Francisco, CA
Full Time

Published on 11/18/2019