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Senior Scientist, Oncology Discovery Analytics

Job Description

Our Research Scientists are our Inventors. We identify and target steps in disease mechanisms or pathways that could be inhibited or enhanced. Our goal is to isolate a compound that is effective against a disease target. Using innovative thinking, state-of-the-art facilities and robust scientific methodology we collaborate to discover the next medical breakthrough.

We are a global biopharmaceutical leader with a diverse portfolio of prescription medicines, oncology, vaccines and animal health products.

We are driven by our purpose to develop and deliver innovative products that save and improve lives. With 69,000 employees operating in more than 140 countries, we offer state of the art laboratories, plants and offices that are designed to Inspire our employees as we learn, develop and grow in our careers. We are proud of our 125 years of service to humanity and continue to be one of the world’s biggest investors in Research & Development.

The Oncology Genomics and Analytics (OGA) team is seeking a passionate and creative computational biologist to help discover the next wave of cancer therapies. Oncology research at our company is driven by a deep interest in the intrinsic biology of cancer cells as well as the complex intercellular interactions in the tumor microenvironment, and how diverse points of intervention can be combined to achieve ever-higher rates of durable response and patient survival. You will collaborate closely with colleagues in Discovery Research and will be based at our Research Laboratories in Boston, MA.

In this exciting role, you will:

  • Interrogate genomics and transcriptomics datasets to aid in the discovery of novel cancer targets. Help experimental scientists characterize novel targets coming from  genetics, translational and disease pathway exploration, explore target engagement, research mechanisms of action, and provide functional validation of novel drug targets.

  • Be proactive and work collaboratively, as well as communicate effectively with various project teams across scientific disciplines and functions, bringing together genetics, pharmacology, chemistry and molecular biology.

  • Contribute to iterative experimental design and mechanistic hypotheses generation through the mining and interpretation of complex biological data.

  • Collaborate with team members to provide support in statistical analyses for testing hypotheses across multiple datasets.

  • Automate large genomic datasets integration, apply machine learning methods to identify and nominate novel targets.

In addition, but not limited to, you will:

  • Lead efforts on the experimental design, analysis and interpretation of DNA and RNA sequencing experiments in support of discovery research programs

  • Identify, analyze and integrate internal and external data and knowledge resources to enable data mining in a biological context to inform target validation and mechanism of action

  •  Engage with Discovery Teams to interrogate data using computational and statistical methods.  

  • Work with in-house, open-source and/or commercially available software platforms for the processing and analysis of DNA and RNA data

  • Assist with project management by coordinating efforts with internal and external collaborators

  • Survey the literature on novel bioinformatics and statistical analysis methodology and algorithms and introduce them in-house when appropriate.

Education Minimum Requirement:

  • Ph.D. in Computational Biology, Biostatistics, Statistics, Mathematics, Computer Science, Molecular Biology, or a related field

Required Experience and Skills:

  • Experience with data transformation, integration, mining and analyses to generate new testable hypotheses.

  • Demonstrated experience on the computational analysis and interpretation of large-scale DNA and/or RNA sequencing datasets

  • Experience in experimental design, statistical hypothesis testing, and inference.

  • Proficiency in statistical programming languages, such as R or Python

  • Excellent attention to detail and strong communication (oral and written) skills

  • Highly self-motivated and capable of prioritizing deliverables among multiple simultaneous projects

  • Builds strong relationships within highly collaborative, multidisciplinary teams

Preferred Experience and Skills:

  • Previous experience in analyzing DNA and RNA data

  • Knowledge of cancer genetics, cancer biology and immunology

  • Experience in application of statistical methodologies on large genomic datasets with clinical covariates.

  • Application of machine learning methods on genomics datasets.

  • Familiarity with public databases and repositories of DNA and RNA profiling data

  • Capable of integrating information generated from multiple sources to strengthen research hypotheses

  • Experience with high-performance Linux cluster and cloud computing

  • Strong publication record

We are a research-driven biopharmaceutical company. Our mission is built on the simple premise that if we “follow the science” that great medicines can make a significant impact to our world. We believe that a research-driven enterprise dedicated to world-class science can succeed by inventing medicine and vaccine innovations that make a difference for patients across the globe. 

Who we are …

We are known as Merck & Co., Inc., Kenilworth, New Jersey, USA in the United States and Canada and MSD everywhere else. For more than a century, we have been inventing for life, bringing forward medicines and vaccines for many of the world's most challenging diseases. Today, our company continues to be at the forefront of research to deliver innovative health solutions and advance the prevention and treatment of diseases that threaten people and animals around the world.

What we look for …

In a world of rapid innovation, we seek brave Inventors who want to make an Impact in all aspects of our business, enabling breakthroughs that will affect generations to come. We encourage you to bring your disruptive thinking, collaborative spirit and diverse perspective to our organization. Together we will continue Inventing For Life, Impacting Lives while Inspiring Your Career Growth.

Invent. Impact. Inspire.


In accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.

If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.

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Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

For more information about personal rights under Equal Employment Opportunity, visit:

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We are proud to be a company that embraces the value of bringing diverse, talented, and committed people together. The fastest way to breakthrough innovation is when diverse ideas come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. We are an equal opportunity employer, committed to fostering an inclusive and diverse workplace.

Search Firm Representatives Please Read Carefully 
Merck & Co., Inc., Kenilworth, NJ, USA, also known as Merck Sharp & Dohme Corp., Kenilworth, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company.  No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. 

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Requisition ID:R115710

Senior Scientist, Oncology Discovery Analytics

Boston, MA
Full Time

Published on 06/10/2021

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