Scientist I/II, Protein Expression and Purification

Location: San Diego, CA

Job Type: Full-Time

Compensation: $90,000 to $120,000

Position Overview

We are seeking a Scientist I/II, Enzyme Assay & Characterization to play a key role in developing and executing biochemical assays that support the company's multi-omics platform development. This individual will optimize and implement assays.

The Scientist I/II will contribute directly to enzyme evaluation. This role offers opportunities for broad technical growth, including assay development, molecular biology, protein engineering and integration.

The candidate must be detail-oriented, analytical, and collaborative, thriving in a dynamic environment that values innovation, cross-disciplinary interaction, and scientific rigor.

Key Responsibilities

• Clone, express, and screen protein constructs in bacterial expression systems.
• Optimize bacterial expression conditions.
• Execute purification workflows.
• Characterize protein quality.
• Optimize and implement biochemical assays.
• Develop, optimize, and validate spectroscopic and fluorescence-based assays.
• Troubleshoot and refine assays for reproducibility, sensitivity, and throughput.
• Collaborate closely with protein expression/purification, enzymology, protein engineering, and molecular biology teams.
• Document methods, maintain rigorous records, contribute to SOPs and prepare data summaries and reports.
• Support lab organization, maintain equipment, and ensure compliance with safety and reproducibility practices.

Qualifications

• B.S. in Biochemistry, Molecular Biology, Enzymology, or related field with 2-6 years of relevant experience, OR M.S. with 0-4 years of relevant experience. Level of position will depend on educational credential and years of experience.
• Demonstrated experience optimizing and implementing biochemical assays.
• Hands-on experience with spectroscopic and fluorescence-based assays.
• Hands-on experience with gel electrophoresis and gel-based assays.
• Strong experience with data visualization software.
• Excellent organizational, problem-solving, and communication skills.
• Ability to work independently and collaboratively in cross-functional teams.

Why Join Us

• Influence the foundational technologies and strategies of a company poised to shape the future of clinical genomics and healthcare.
• Work in a dynamic, collaborative environment where innovation and scientific rigor are deeply valued.
• Join a seasoned and multidisciplinary team tackling high-impact problems at the intersection of science and engineering.
• Competitive compensation and equity package, comprehensive benefits, and flexibility to support work-life integration.

We are an equal opportunity employer. We thrive on diversity and collaboration.