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Senior Scientist - Oligo Bioinformatics

Work Location: Billerica, Massachusetts
Shift: No
Department: HC-RD-XO4 Oligonucleotide Chemical Conjugation
Recruiter: Beverly Dellisola

This information is for internals only. Please do not share outside of the organization.

Your Role:

EMD Serono in Billerica, MA is seeking a Senior Scientist - Oligo Bioinformatics to add to their Oligonucleotide Therapeutics Group (DDTech).

Responsibilities:

  • Utilize Bioinformatics platforms to design, evaluate and optimize siRNA sequences for targeted gene silencing
  • Analyze gene expression data to identify suitable targets for siRNA/ASO development
  • Work closely with chemists and biologists to integrate bioinformatics approaches into experimental workflow
  • Perform transcriptome wide off-target prediction and annotation
  • Develop pipelines that determine mapping coordinates and homology of oligonucleotides to genomes and transcriptomes

Who You Are:

Minimum Qualifications:

  • PhD in Chemistry, Chemical Engineering or other Science or Engineering discipline with 3+ years of direct experience Oligonucleotide field

Preferred Qualifications:

  • Strong scientific curiosity and innovation mindset
  • Proficient in Bioinformatics tools and software (e.g. BLAST, RNA fold, siRNA design tools)
  • Ability to analyze large genomic and transcriptomic datasets including RNA seq, Single cell RNA seq, splice isoforms and variant database
  • Highly collaborative with strong problem-solving ability

Pay Range for this position: $112,800 - $169,200

The Company is an Equal Employment Opportunity employer. No employee or applicant for employment will be discriminated against on the basis of race, color, religion, age, sex, sexual orientation, national origin, ancestry, disability, military or veteran status, genetic information, gender identity, transgender status, marital status, or any other classification protected by applicable federal, state, or local law. This policy of Equal Employment Opportunity applies to all policies and programs relating to recruitment and hiring, promotion, compensation, benefits, discipline, termination, and all other terms and conditions of employment. Any applicant or employee who believes they have been discriminated against by the Company or anyone acting on behalf of the Company must report any concerns to their Human Resources Business Partner, Legal, or Compliance immediately. The Company will not retaliate against any individual because they made a good faith report of discrimination.

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Senior Scientist - Oligo Bioinformatics

Merck Group
Billerica, MA
Full Time
USD 112,800.00 - 169,200.00 per year

Published on 06/13/2026

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